Assessment of pharmacodynamic and pharmacokinetic characteristics of drugs using microdialysis sampling and capillary electrophoresis.

@article{Denoroy1998AssessmentOP,
  title={Assessment of pharmacodynamic and pharmacokinetic characteristics of drugs using microdialysis sampling and capillary electrophoresis.},
  author={Luc Denoroy and Lionel Bert and Sandrine Parrot and Fr{\'e}d{\'e}ric Robert and Bernard Renaud},
  journal={Electrophoresis},
  year={1998},
  volume={19 16-17},
  pages={2841-7}
}
Microdialysis sampling combined with capillary electrophoresis is emerging as a new approach in drug studies. It allows the continuous monitoring, in vivo or in vitro, of changes in free endogenous compounds as well as in drug substances, following the administration of pharmacological agents. The low volume requirement of capillary electrophoresis for injection allows the collection of dialysates during short sampling times, leading to a precise temporal description of drug-induced biochemical… CONTINUE READING