Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays.

@article{Nguyen2010AssessmentOP,
  title={Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays.},
  author={Ha Thi Thuy Nguyen and Tiffany G. Sheu and Vasiliy P. Mishin and Alexander I. Klimov and Larisa V. Gubareva},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 9},
  pages={3671-7}
}
The neuraminidase inhibitors (NAIs) zanamivir and oseltamivir are currently the only antiviral drugs effective for the treatment and prophylaxis of 2009 pandemic influenza A (H1N1) virus infections. The proven potential of these viruses to acquire NAI resistance during treatment emphasizes the need to assess their NAI susceptibility. The 50% inhibitory concentrations (IC(50)s) are known to vary depending on the neuraminidase inhibition (NI) test used; however, few side-by-side comparisons of… CONTINUE READING

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Human influenza A viruses isolated in South America: genetic relations, adamantane resistance and vaccine strain match.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases • 2009

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