Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in multiple endocrine neoplasia (MEN1) syndrome patients without any detectable MEN1 gene mutations.

@article{Igreja2009AssessmentOP,
  title={Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in multiple endocrine neoplasia (MEN1) syndrome patients without any detectable MEN1 gene mutations.},
  author={Susana C Igreja and Harvinder S. Chahal and Scott A. Akker and Maria Gueorguiev and Vera Popovi{\'c} and Svetozar Damjanovic and Pia Burman and John A.H. Wass and Richard Quinton and Ashley B. Grossman and M{\'a}rta Korbonits},
  journal={Clinical endocrinology},
  year={2009},
  volume={70 2},
  pages={
          259-64
        }
}
OBJECTIVE Germline mutations in the MEN1 gene predispose to the multiple endocrine neoplasia (MEN1) syndrome; however, approximately 10-20% of patients with MEN1 do not have a detectable MEN1 mutation. A rat strain with multiple endocrine tumours, a phenotypic overlap of both MEN1 and MEN2, has been reported to have a homozygous germline p27 (CDKN1B) mutation. Recently, two MEN1 mutation-negative MEN1 syndrome patients have been identified to harbour a germline CDKN1B mutation. The recently… CONTINUE READING
Highly Cited
This paper has 27 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 citations