Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid®

@article{Bhamidipati2010AssessmentOO,
  title={Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid®},
  author={Ravikanth Bhamidipati and P. Venkatesh and P. Dravid and Prasad C. Narasimhulu and Sastry Tvrs and J. Das and R. Mullangi and N. R. Srinivas},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={30},
  pages={187-193}
}
  • Ravikanth Bhamidipati, P. Venkatesh, +5 authors N. R. Srinivas
  • Published 2010
  • Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
  • SummaryThe aim of this study was to determine the bioavailability of a novel oxazolidinone, DRF-6196, in mice and rats followingintravenous (i.v) and oral dosing and to compare the pharmacokinetics with those obtained following linezolid dosing. Blood samples were drawn at predetermined intervals up to 24 h post-dose after either DRF-6196 or linezolid administration. The concentrations of DRF-6196 and linezolid in various plasma samples were determined by a HPLC method. Following oral… CONTINUE READING

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