Assessment of nuclear and cytoplasmic maturation in in-vitro matured human oocytes.

@article{Combelles2002AssessmentON,
  title={Assessment of nuclear and cytoplasmic maturation in in-vitro matured human oocytes.},
  author={Catherine M. H. Combelles and Natalie A Cekleniak and Catherine Racowsky and David F Albertini},
  journal={Human reproduction},
  year={2002},
  volume={17 4},
  pages={1006-16}
}
BACKGROUND With improved prospects for the use of human oocyte in-vitro maturation in assisted reproductive technologies, the need to define more clearly the coordination of nuclear and cytoplasmic maturation has arisen. METHODS Immunofluorescence and confocal microscopy were used to evaluate cell cycle-dependent modifications in chromatin and microtubules in human germinal vesicle oocytes (n = 455) undergoing in-vitro maturation. RESULTS Four distinct classes of germinal vesicle stage… CONTINUE READING
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