Assessment of normal and tumor tissue uptake of MAG-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma

@article{Sarapa2003AssessmentON,
  title={Assessment of normal and tumor tissue uptake of MAG-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma},
  author={Nenad Sarapa and Margaret R. Britto and William Speed and MariaGabriella Jannuzzo and Massimo Breda and Christopher A. James and MariaGrazia Porro and Maurizio Rocchetti and Alkvin Wanders and Haile Mahteme and P. -{\AA}. Nygren},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2003},
  volume={52},
  pages={424-430}
}
MAG-camptothecin (MAG-CPT) is the lead compound of a novel drug delivery system in which an active cytotoxic moiety, camptothecin (CPT), is covalently linked to a soluble polymeric carrier (MAG) to form an inactive prodrug. The mechanism of action of CPT remains unaltered, but the delivery system is thought to allow the carrier-bound drug to accumulate in tumor tissues and release the active CPT locally. This proof-of-concept clinical study was designed to determine whether MAG-CPT was… CONTINUE READING
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Phase I pharmacokinetic (PK) study of MAG-CPT (PNU-166148), a polymeric derivative of camptothecin (CPT) (abstract 771)

  • JS de Bono, D Bissett, C Twelves, M Cassidy
  • Proc ASCO 19:198a
  • 2000
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