Assessment of non-BDNF neurotrophins and GDNF levels after depression treatment with sertraline and transcranial direct current stimulation in a factorial, randomized, sham-controlled trial (SELECT-TDCS): An exploratory analysis

@article{Brunoni2015AssessmentON,
  title={Assessment of non-BDNF neurotrophins and GDNF levels after depression treatment with sertraline and transcranial direct current stimulation in a factorial, randomized, sham-controlled trial (SELECT-TDCS): An exploratory analysis},
  author={Andr{\'e} Russowsky Brunoni and Rodrigo Machado-Vieira and Carlos A. Zarate and Erica Leandro Marciano Vieira and Ant{\^o}nio L{\'u}cio Teixeira},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2015},
  volume={56},
  pages={91-96}
}
The neurotrophic hypothesis of depression states that the major depressive episode is associated with lower neurotrophic factors levels, which increase with amelioration of depressive symptoms. However, this hypothesis has not been extended to investigate neurotrophic factors other than the brain-derived neurotrophic factor (BDNF). We therefore explored whether plasma levels of neurotrophins 3 (NT-3) and 4 (NT-4), nerve growth factor (NGF) and glial cell line derived neurotrophic factor (GDNF… CONTINUE READING
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