Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop.

Abstract

We report the synthesis of two new artificial nucleobase scaffolds, 1 and 2, featuring adequate hydrogen bonding donors and acceptors for the molecular recognition of U:A and C:G base pairs, respectively. The tethering of these structures to various amino acids and the assessment of these artificial nucleobase-amino acid conjugates as RNA ligands against a model of HCV IRES IIId domain are also reported. Compound 1e displayed the highest affinity (Kd twice lower than neomycin - control). Moreover, it appears that this interaction is enthalpically and entropically favored.

DOI: 10.1016/j.bmcl.2017.02.061

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Cite this paper

@article{Filho2017AssessmentON, title={Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop.}, author={Mauro Safir Filho and Anthony R Martin and Rachid Benhida}, journal={Bioorganic & medicinal chemistry letters}, year={2017}, volume={27 8}, pages={1780-1783} }