Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

@inproceedings{Martin2011AssessmentON,
  title={Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks},
  author={Florian Martin and Ty M. Thomson and Alain Sewer and David A. Drubin and Carole Mathis and Dirk Weisensee and Dexter Pratt and Julia Hoeng and Manuel C. Peitsch},
  booktitle={BMC Systems Biology},
  year={2011}
}
BackgroundHigh-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease, drug treatment, and environmental agents on humans. The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately characterize biological processes that have been perturbed at the mechanistic level. Here, a new approach is built on previous methodologies in which high-throughput data was interpreted using… CONTINUE READING
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