Assessment of myelotoxicity caused by environmental chemicals.

  title={Assessment of myelotoxicity caused by environmental chemicals.},
  author={Gary A. Boorman and Michael I. Luster and Jack H. Dean and Martin L. Campbell},
  journal={Environmental Health Perspectives},
  pages={129 - 135}
Potential antineoplastic agents must be screened for the delayed toxicity that occurs in many cases of drug-induced bone marrow aplasia. In vitro clonal assays for hematopoietic progenitor cells have been developed to assess the degree of myelotoxicity. This adverse side effect is often the limiting factor in the development of new cancer chemotherapeutics. In addition, many environmental chemicals are cytotoxic to rapidly proliferating cells, but a systematic assessment of their myelotoxicity… CONTINUE READING
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