Assessment of myeloperoxidase activity in whole rat kidney.

  title={Assessment of myeloperoxidase activity in whole rat kidney.},
  author={L. M. Hillegass and Don E. Griswold and B M Brickson and Christine Albrightson-Winslow},
  journal={Journal of pharmacological methods},
  volume={24 4},
A method to quantitate myeloperoxidase (MPO) activity from rat whole kidney is described. Polymorphonuclear leukocyte (PMN) infiltration into tissue is a hallmark of acute inflammation. Historically, the degree of inflammation has been quantified by the identification and enumeration of PMNs histologically or by some other means. More recently, the enzyme activity of MPO, a marker enzyme for PMN, and freshly emigrated monocytes in many inflamed tissues has replaced these methods. The kidney… CONTINUE READING
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