Assessment of mitochondrial electron transport chain function in a primary astrocyte cell model of hyperhomocystinaemia.

@article{Turkes2013AssessmentOM,
  title={Assessment of mitochondrial electron transport chain function in a primary astrocyte cell model of hyperhomocystinaemia.},
  author={Fiona Turkes and Elaine Murphy and John Land and Berna Demiray and Kate E. C. Duberley and Antony Briddon and Iain P. Hargreaves},
  journal={Toxicology mechanisms and methods},
  year={2013},
  volume={23 6},
  pages={459-63}
}
Elevated plasma homocysteine (Hcy) has been detected in patients with various neurodegenerative conditions. Studies on neurones and cerebral tissue have revealed that hyperhomocystinaemia may inhibit mitochondrial electron transport chain (ETC) enzyme activity resulting in neuronal morbidity. As astrocytes convey a protective and supportive role towards neurones, we postulated that Hcy-induced astrocytic ETC inhibition may contribute to neurological dysfunction. In order to investigate this… CONTINUE READING

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