Assessment of mitochondrial dysfunction arising from treatment with hepatotoxicants.


Mitochondrial dysfunction from toxicants is recognized as a causative factor in the development of numerous liver diseases including steatohepatitis, cirrhosis, and cancer. Toxicant-mediated damage to mitochondria result in depressed ATP production, inability to maintain proper cellular calcium homeostasis, and increased reactive oxygen species production… (More)
DOI: 10.1002/0471140856.tx1408s44