Assessment of minimal residual disease (MRD) in CBFbeta/MYH11-positive acute myeloid leukemias by qualitative and quantitative RT-PCR amplification of fusion transcripts

@article{Guerrasio2002AssessmentOM,
  title={Assessment of minimal residual disease (MRD) in CBFbeta/MYH11-positive acute myeloid leukemias by qualitative and quantitative RT-PCR amplification of fusion transcripts},
  author={Angelo Guerrasio and Chiara Pilatrino and Denise De Micheli and Daniela Cilloni and Anna Serra and Enrico Gottardi and Antonio Parziale and Filippo Marmont and Daniela Diverio and Mariadomenica Divona and Francesco Lo Coco and Giuseppe Saglio},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={1176-1181}
}
The inv(16)(p13q22) chromosomal rearrangement associated with FAB M4Eo acute myeloid leukemia (AML) subtype is characterized by the presence of the CBFbeta/MYH11 fusion transcript that can be used to detect minimal residual disease (MRD). However, qualitative RT-PCR studies of MRD have so far produced conflicting results and seem of limited prognostic value. We have evaluated retrospectively MRD in a large series of CBFbeta/MYH11-positive patients employing both qualitative and quantitative… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

Detection and quantitation of CBFB/MYH11 fusion transcript in patients with inv(16) positive acute myeloblastic leukemia by real-time RT-PCR

J Krauter, W Hoellge, +5 authors G. Heil
Genes Chromos Cancer • 2001

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