Assessment of mineralocorticoid activity in the rabbit colon.

  title={Assessment of mineralocorticoid activity in the rabbit colon.},
  author={Diana Marver},
  journal={The American journal of physiology},
  volume={246 4 Pt 2},
  • Diana Marver
  • Published 1984 in The American journal of physiology
Analyses of [3H]corticosteroid binding sites in distal colon indicated high-affinity binding sites or receptors for both [3H]aldosterone (Type I, Kd = 6.5 X 10(-9) M) and [3H]dexamethasone (Type II, Kd = 5.5 X 10(-8) M). The relative affinity of dexamethasone (D) was 1/20 that of aldosterone (A) for Type I sites and the affinity of A for Type II sites was 1/50 that of D at 37 degrees C. Citrate synthase (CS) activity was assayed and found to be reduced in enterocytes harvested from… CONTINUE READING

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