Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

@inproceedings{Livingstone2015AssessmentOM,
  title={Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes},
  author={Mark Alexander Livingstone and Kristina Sikstr{\"o}m and Philippe A. Robert and Gilles Uz{\'e} and Ola Larsson and Sandra Pellegrini and Gordon Langsley},
  booktitle={PloS one},
  year={2015}
}
Type-I interferon (IFN)-induced activation of the mammalian target of rapamycin (mTOR) signaling pathway has been implicated in translational control of mRNAs encoding interferon-stimulated genes (ISGs). However, mTOR-sensitive translatomes commonly include mRNAs with a 5' terminal oligopyrimidine tract (TOP), such as those encoding ribosomal proteins, but not ISGs. Because these translatomes were obtained under conditions when ISG expression is not induced, we examined the mTOR-sensitive… CONTINUE READING

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

New function of type I IFN: induction of autophagy.

  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2014
VIEW 1 EXCERPT