Assessment of liquid microbead arrays for the screening of newborns for spinal muscular atrophy.

@article{Pyatt2007AssessmentOL,
  title={Assessment of liquid microbead arrays for the screening of newborns for spinal muscular atrophy.},
  author={Robert E. Pyatt and David C Mihal and Thomas W. Prior},
  journal={Clinical chemistry},
  year={2007},
  volume={53 11},
  pages={1879-85}
}
BACKGROUND Spinal muscular atrophy is a common neurodegenerative disorder that has recently been considered for inclusion in the next generation of newborn screening regimens. We sought to validate liquid microbead arrays for the identification of affected individuals by direct DNA analysis. METHODS Assays were created to detect the homozygous deletions in exon 7 of the SMN1 gene found in approximately 95% of affected individuals by use of 2 different microbead chemistries on the Luminex 200… CONTINUE READING
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