Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease.

Abstract

BACKGROUND/AIM The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). POPULATION AND METHODS Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]. The data were evaluated with SPSS using "Student t and Mann-Whitney U" tests. RESULTS The study group children (n: 43) had higher LDL, Lp(a) and ox-LDL levels, ratios of TC/HDL, Apo-B/A, LDL/HDL and ox-LDL/HDL (p<0.05) than control group. CONCLUSION These findings suggest that dyslipidemia and increased LDL, Lp(a) and ox-LDL levels are common in the offspring of patients with early onset CHD and account largely for their familial predisposition for CHD.

DOI: 10.5546/aap.2017.eng.50

Cite this paper

@article{Bornaun2017AssessmentOL, title={Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease.}, author={Helen Bornaun and Naci {\"{O}ner and Kemal Nişli and Kazım {\"{O}ztarhan and Taner Yavuz and {\"{U}mit T{\"{u}rkoğlu and Ayg{\"{u}n Dindar and Rukiye Eker {\"{O}meroglu}, journal={Archivos argentinos de pediatria}, year={2017}, volume={115 1}, pages={50-54} }