Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

@article{Olsen2007AssessmentOL,
  title={Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers},
  author={Geary W. Olsen and Larry R. Zobel},
  journal={International Archives of Occupational and Environmental Health},
  year={2007},
  volume={81},
  pages={231-246}
}
  • G. OlsenL. R. Zobel
  • Published 29 June 2007
  • Medicine
  • International Archives of Occupational and Environmental Health
ObjectivesPerfluorooctanoic acid (PFOA) results in peroxisome proliferator mediated effects in rats and mice resulting in hypolipidemia but not in monkeys. Counterintuitive modestly positive associations between PFOA and cholesterol levels in production workers have been inconsistently reported. The purpose of this assessment was to examine this association in male workers who manufactured or used PFOA at three facilities.MethodsSubjects were male employee voluntary participants of a… 

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It is concluded that a higher serum concentration of PFOA may cause liver enzymes to increase abnormally in the general population, particularly in obese individuals.

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Reductions in Serum Lipids with a 4-year Decline in Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid

Previous evidence from cross-sectional studies of positive associations between PFOA and PFOS in serum and LDL cholesterol support the findings from this longitudinal study, which is less susceptible to biases from uncontrolled confounding or reverse causality.

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Adverse associations were not observed between changes in PFOA, PFOS, non-HDL cholesterol, HDL, and hepatic clinical chemistries.

Perfluoroalkyl substances and thyroid function in older adults.

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