Assessment of ligand binding residue predictions in CASP8.

  title={Assessment of ligand binding residue predictions in CASP8.},
  author={Gonzalo L{\'o}pez and Iakes Ezkurdia and Michael L. Tress},
  volume={77 Suppl 9},
Here we detail the assessment process for the binding site prediction category of the eighth Critical Assessment of Protein Structure Prediction experiment (CASP8). Predictions were only evaluated for those targets that bound biologically relevant ligands and were assessed using the Matthews Correlation Coefficient. The results of the analysis clearly demonstrate that three predictors from two groups (Lee and Sternberg) stand out from the rest. A further two groups perform well over subsets of… CONTINUE READING