Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI.

@article{Tietze2014AssessmentOI,
  title={Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI.},
  author={Anna Tietze and Jakob Udby Blicher and Irene Klaerke Mikkelsen and Leif \Ostergaard and M K Strother and Seth A. Smith and Manus J. Donahue},
  journal={NMR in biomedicine},
  year={2014},
  volume={27 2},
  pages={163-74}
}
Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton transfer (APT) MRI has shown promise in animal studies for the prediction of infarction risk in ischemic tissue. Here, APT MRI was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments of APT contrast, perfusion, diffusion, disability and final… CONTINUE READING