Assessment of inter-individual variability in predicted phenytoin clearance


To assess the inter-individual variability in phenytoin (PHT) clearance predicted from in vitro kinetic data. The Simcyp Population-based ADME Simulator was used to predict the clearance of PHT from reported in vitro kinetic data generated in the absence or presence of albumin. Liver intrinsic clearance (CLint.liver) was calculated from pharmacokinetic… (More)
DOI: 10.1007/s00228-009-0703-y


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