Assessment of ileal epithelial P-glycoprotein dysfunction induced by ischemia/reperfusion using in vivo animal model.

@article{Tomita2008AssessmentOI,
  title={Assessment of ileal epithelial P-glycoprotein dysfunction induced by ischemia/reperfusion using in vivo animal model.},
  author={Mikio Tomita and Yusuke Takizawa and Hisanao Kishimoto and Masahiro Hayashi},
  journal={Drug metabolism and pharmacokinetics},
  year={2008},
  volume={23 5},
  pages={356-63}
}
We presented the ischemia/reperfusion (I/R) model which can evaluate changes in P-glycoprotein (P-gp) function induced by lipid peroxidation using surgical-sutures connected with the spring balance. The superior mesenteric artery and vein was occluded by hanging itself using surgical-sutures connected with the spring balance for 60 min (ischemia), followed by reperfusion by cutting of sutures. To determine the hanging force of blood vessel during ischemia, treatment at the hanging force of 50g… CONTINUE READING
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