Assessment of human muscle glycogen synthesis and total glucose content by in vivo 13C MRS.

@article{Bergh2000AssessmentOH,
  title={Assessment of human muscle glycogen synthesis and total glucose content by in vivo 13C MRS.},
  author={Adrianus J van den Bergh and Cees J.J. Tack and H J van den Boogert and Gerald M. M. Vervoort and P. G. F. M. Smits and Arend Heerschap},
  journal={European journal of clinical investigation},
  year={2000},
  volume={30 2},
  pages={122-8}
}
BACKGROUND Obesity is often accompanied by a decreased ability of insulin to stimulate glucose uptake and glycogenesis in skeletal muscle. The aim of this study was to investigate the rate of glycogen formation and of muscular glucose content in relation to insulin sensitivity under euglycemic conditions. MATERIALS AND METHODS We applied a hyperinsulinemic (430 pmol m-2 min-1) euglycemic clamp with infusion of 20% glucose (30% enriched with 13C-1-glucose) to 8 subjects with a wide range of… CONTINUE READING

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