Assessment of hepatic function in rabbits with steroid-induced cholestatic liver injury.

@article{Tennant1981AssessmentOH,
  title={Assessment of hepatic function in rabbits with steroid-induced cholestatic liver injury.},
  author={Bud Christopher Tennant and Tania C Balazs and Betty H Baldwin and William E. Hornbuckle and William L. Castleman and Urs Alex Boelsterli and Francis A. Kallfelz},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1981},
  volume={1 4},
  pages={329-33}
}
Methyltestosterone (MT) or ethinyl estradiol (EE) was administered to adult rabbits for 20 weeks beginning with initial daily doses of 0.4 mg/kg MT and 0.015 mg/kg EE for three weeks, then these dosages were doubled at 3-week intervals to a maximum dosages 6.4 mg/kg and 0.24 mg/kg, respectively. Within 2 weeks, the serum gamma-glutamyltransferase activity of MT and EE treated rabbits was significantly greater than controls and increased progressively throughout the treatment period. Aspartate… CONTINUE READING