Assessment of genetic and epigenetic variation during long-term Taxus cell culture

@article{Fu2012AssessmentOG,
  title={Assessment of genetic and epigenetic variation during long-term Taxus cell culture},
  author={Chunhua Fu and Liqin Li and Wenjuan Wu and Maoteng Li and Xiaoqing Yu and Long-jiang Yu},
  journal={Plant Cell Reports},
  year={2012},
  volume={31},
  pages={1321-1331}
}
Gradual loss of secondary metabolite production is a common obstacle in the development of a large-scale plant cell production system. In this study, cell morphology, paclitaxel (Taxol®) biosynthetic ability, and genetic and epigenetic variations in the long-term culture of Taxus media cv Hicksii cells were assessed over a 5-year period to evaluate the mechanisms of the loss of secondary metabolites biosynthesis capacity in Taxus cell. The results revealed that morphological variations, gradual… CONTINUE READING
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