Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration.

@article{Hidalgo2006AssessmentOG,
  title={Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration.},
  author={Maartje Hidalgo and Maria de la Luz Olvera Amador and Antonio J. Jimeno and Heather M Mezzadra and Pina M Patel and Audrey Chan and Matthew E Nielsen and Anirban Maitra and Soner Altiok},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 7},
  pages={1895-903}
}
One specific limitation to the clinical development of targeted cancer therapeutics is the lack of well-validated pharmacodynamic markers. Such tools might conceivably provide a framework within which to better evaluate the selection of specific molecules as therapeutic targets. Nevertheless, the practical application of this hypothesis in clinical… CONTINUE READING