Assessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interface.

Abstract

Computational protein design methods can complement experimental screening and selection techniques by predicting libraries of low-energy sequences compatible with a desired structure and function. Incorporating backbone flexibility in computational design allows conformational adjustments that should broaden the range of predicted low-energy sequences… (More)
DOI: 10.1002/pro.632

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Cite this paper

@article{Babor2011AssessmentOF, title={Assessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interface.}, author={Mariana Babor and Daniel J. Mandell and Tanja Kortemme}, journal={Protein science : a publication of the Protein Society}, year={2011}, volume={20 6}, pages={1082-9} }