Assessment of factors regulating axon growth between the cortex and spinal cord in organotypic co-cultures: effects of age and neurotrophic factors.

@article{Oishi2004AssessmentOF,
  title={Assessment of factors regulating axon growth between the cortex and spinal cord in organotypic co-cultures: effects of age and neurotrophic factors.},
  author={Yosuke Oishi and Janie Baratta and Richard T. Robertson and Oswald Steward},
  journal={Journal of neurotrauma},
  year={2004},
  volume={21 3},
  pages={339-56}
}
Axon growth failure in the central nervous system (CNS) of adult animals is thought to be attributable to several factors, including an inadequate intrinsic growth response, the presence of inhibitory molecules, and a lack of adequate neurotrophic support. Here we use a new in vitro assay system to quantitatively assess growth of axons in cortex/spinal cord organotypic co-cultures from neonatal rats. Co-cultures of cortex and spinal cord were prepared from neonatal rats at P3 or P7, and by… CONTINUE READING

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