Assessment of environmental hazards of 1,3,5-trinitrobenzene.

@article{Reddy1997AssessmentOE,
  title={Assessment of environmental hazards of 1,3,5-trinitrobenzene.},
  author={G. Reddy and T. Reddy and H. Choudhury and F. Daniel and G. Leach},
  journal={Journal of toxicology and environmental health},
  year={1997},
  volume={52 5},
  pages={
          447-60
        }
}
The remedial investigation/feasibility studies conducted at certain Army installations showed a need to clean up contaminated sites, where high levels of ammunition chemicals such as 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitrobenzene (TNB), 1,3-dinitrobenzene (DNB), and their degradation products/metabolites were detected in surface soil and groundwater. TNB is a photodegradation product of TNT; it is not easily degraded, and persists in the environment. The toxicity data on TNB are scanty… Expand
Wildlife Toxicity Assessment for 1,3,5-Trinitrobenzene (TNB)
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Abstract : Nitroaromatics, such as 1 ,3-dinitrobenzene (DNB), 1 ,3,5-trinitrobenzene (TN B), and N-methyl-N,2,4,6-tetranitroaniline (tetryl), have been detected as environmental contaminants ofExpand
Reproductive Toxicity Screen of 1,3,5-Trinitrobenzene Administered in the Diet of Sprague-Dawley Rats
TLDR
A modified Screening Information Data Set (SIDS) reproductive study was performed on Sprague-Dawley rats, finding methemoglobinemia and splenic hemosiderosis were common findings in the high- and mid-dose levels of both sexes at necropsy. Expand
Subchronic Toxicity Studies on 1,3,5-Trinitrobenzene, 1,3- Dinitrobenzene, and Tetryl in Rats. Subchronic Toxicity Evaluation of 1,3,5- Trinitrobenzene in Fischer 344 Rats
Subchronic toxic effects of 1,3,5-trinitrobenzene (TNB) in male and female Fischer 344 rats were evaluated by feeding powdered certified laboratory chow diet supplemented with varied concentrationsExpand
1,3-dinitrobenzene: toxic effects in vivo and in vitro.
TLDR
Signs of toxicity included reduction in ambulatory motion, ataxia, weaknes, dyspnea, rapid heartbeat, cyanosis, coma, and eventual respiratory failure in rats given 1,3-dinitrobenzene orally as a 1% suspension in corn oil. Expand
Mutagenicity in Salmonella typhimurium and structure-activity relationships of wastewater components emanating from the manufacture of trinitrotoluene.
TLDR
The mutagenic response of isomeric DNTs was found to correlate with the compound's ability to undergo charge-transfer complexation with reductive enzymes, whereas further complexation appears to be required for inducing mutation in dinitrobenzenes. Expand
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A series of nitrated toluenes and benzene were tested for their capability to act as initiators, promoters or complete carcinogens in mouse skin. 2,6- dinitrotoluenes and 2-nitrotoluene were found toExpand
Genotoxic activity in microorganisms of tetryl, 1,3-dinitrobenzene and 1,3,5-trinitrobenzene.
TLDR
In this segment of a programme initiated by military authorities, the genotoxic potential of three nitroaromatic compounds, which have found significant use in explosive preparations, has been demonstrated. Expand
Identification of TNT Transformation Products in Soil
Abstract : Solvent-extractable TNT transformation products have been identified in explosive-contaminated soils. Soils from U.S. Army installations were extracted with a variety of solventsExpand
Fourteen‐day Toxicity Study of 1,3,5‐Trinitrobenzene in Fischer 344 Rats
TLDR
Hematology and clinical chemistry studies indicated a decrease in red blood cell count and hematocrit, a decreases in alkaline phosphatase, an increase in Heinz bodies and increased methemoglobin concentration as compared to controls in both sexes. Expand
Subchronic toxicity of trinitrotoluene in Fischer 344 rats.
TLDR
Hemosiderin-laden macrophages, congestion of the splenic red pulp, methemoglobin production indicative of the oxidizing activity of TNT and/or its metabolites, and the lack of bone marrow toxicity suggested hemolysis as the mechanism of anemia. Expand
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