Assessment of energy metabolism in the developing brain following aglycemic hypoxia by1H and31P NMR

@article{Brooks1996AssessmentOE,
  title={Assessment of energy metabolism in the developing brain following aglycemic hypoxia by1H and31P NMR},
  author={Keith J. Brooks and John Bates Clark and Timothy Edward Bates},
  journal={Neurochemical Research},
  year={1996},
  volume={21},
  pages={1089-1095}
}
The role played by external calcium and calcium channels in the recovery from aglycaemic hypoxia in cortical brain slices from 10-day old rats was investigated by1H and31P NMR. 30 minutes of aglycaemic hypoxia significantly decreased the levels of phosphocreatine (PCr), ATP, lactate and intracellular pH (pHi). After a 30 minute recovery period there was incomplete recovery of PCr and ATP with lactate increasing by 50% with pHi normal. When the aglycemic hypoxia was carried out in media which… CONTINUE READING

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