Assessment of emerging biomarkers of liver injury in human subjects.

  title={Assessment of emerging biomarkers of liver injury in human subjects.},
  author={Shelli J. Schomaker and Roscoe 1. Warner and Jeff Bock and Kent Aaron Johnson and David Potter and Joyce Van Winkle and Jiri Aubrecht},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={132 2},
Hepatotoxicity remains a major challenge in drug development. Although alanine aminotransferase (ALT) remains the gold standard biomarker of liver injury, alternative biomarker strategies to better predict the potential for severe drug-induced liver injury (DILI) are essential. In this study, we evaluated the utility of glutamate dehydrogenase (GLDH), purine nucleoside phosphorylase (PNP), malate dehydrogenase (MDH), and paraxonase 1 (PON1) as indicators of liver injury in cohorts of human… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 29 extracted citations

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

Toxicological sciences : an official journal of the Society of Toxicology • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 43 references

Hy's law: predicting serious hepatotoxicity.

Pharmacoepidemiology and drug safety • 2006
View 7 Excerpts
Highly Influenced

Case definition and phenotype standardization in drug-induced liver injury.

Clinical pharmacology and therapeutics • 2011
View 5 Excerpts
Highly Influenced

Glutamate dehydrogenase: biochemical and clinical aspects of an interesting enzyme.

Clinica chimica acta; international journal of clinical chemistry • 1988
View 4 Excerpts
Highly Influenced

Biomarkers In Medicine, Drug Discovery, and Environmental Health

S. V. Vaidya, J. V. Bonventre, Ed.
John Wiley & SOns, Inc., Hoboken, NJ. • 2010

Similar Papers

Loading similar papers…