Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.

@article{Marschall2013AssessmentOD,
  title={Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.},
  author={Manfred Marschall and Ina Niemann and Karin Kosulin and Anna Bootz and Sabrina M Wagner and Thomas Dobner and Thomas Herz and Bernd Kramer and Johann Leban and Daniel Vitt and Thomas Stamminger and Corina Hutterer and Stefan Strobl},
  journal={Antiviral research},
  year={2013},
  volume={100 3},
  pages={640-8}
}
Currently available antiviral drugs frequently induce side-effects or selection of drug-resistant viruses. We describe a novel antiviral principle based on targeting the cellular enzyme dihydroorotate dehydrogenase (DHODH). In silico drug design and biochemical evaluation identified Compound 1 (Cmp1) as a selective inhibitor of human DHODH in vitro (IC50 1.5±0.2nM). Crystallization data specified the mode of drug-target interaction. Importantly, Cmp1 displayed a very potent antiviral activity… CONTINUE READING
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