Assessment of disease progression in motor neuron disease.

  title={Assessment of disease progression in motor neuron disease.},
  author={Jennica M. C. Winhammar and Dominic B Rowe and Robert D. Henderson and Matthew C Kiernan},
  journal={The Lancet. Neurology},
  volume={4 4},
Motor neuron disease (MND) is characterised by progressive deterioration of the corticospinal tract, brainstem, and anterior horn cells of the spinal cord. There is no pathognomonic test for the diagnosis of MND, and physicians rely on clinical criteria-upper and lower motor neuron signs-for diagnosis. The presentations, clinical phenotypes, and outcomes of MND are diverse and have not been combined into a marker of disease progression. No single algorithm combines the findings of functional… CONTINUE READING


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