Assessment of disease activity and impending flare in patients with systemic lupus erythematosus. Comparison of the use of complement split products and conventional measurements of complement.

@article{Buyon1992AssessmentOD,
  title={Assessment of disease activity and impending flare in patients with systemic lupus erythematosus. Comparison of the use of complement split products and conventional measurements of complement.},
  author={J P Buyon and J D Tamerius and H. Michael Belmont and Steven B. Abramson},
  journal={Arthritis and rheumatism},
  year={1992},
  volume={35 9},
  pages={1028-37}
}
OBJECTIVE To determine whether increased levels of the complement split products generated in the activation of the alternative or classical pathway accompany more severe disease activity in patients with systemic lupus erythematosus (SLE) and whether these measurements are useful in predicting flares of disease. METHODS Levels of Ba, Bb, SC5b-9, and C4d were measured in 380 plasma samples obtained from 86 SLE patients who were prospectively followed up for 15 months. RESULTS In the 20… CONTINUE READING
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