Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes.

@article{Gerner2003AssessmentOD,
  title={Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes.},
  author={P{\'e}ter Gerner and Anna E. Haderer and Mustafa Ghulam Mujtaba and Yukari Sudoh and Sanjeet Narang and Salahadin Abdi and Venkatesh Srinivasa and Christof Pertl and G. K. Wang},
  journal={Anesthesiology},
  year={2003},
  volume={98 6},
  pages={
          1484-90
        }
}
BACKGROUND Increasing the duration of local anesthesia and/or creating greater differential blockade (i.e., selective block of pain-transmitting nerve fibers) has been attempted by modifying currently available agents. Most drugs show a different profile depending on the model or species studied. This study was designed to investigate the differential nerve-blocking properties of amitriptyline and its quaternary ammonium derivative in rats and sheep. METHODS The Na+ channel-blocking… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 17 REFERENCES

Similar Papers

Loading similar papers…