Assessment of dermal exposure and histopathologic changes of different sized nano-silver in healthy adult rabbits

@inproceedings{Koohi2011AssessmentOD,
  title={Assessment of dermal exposure and histopathologic changes of different sized nano-silver in healthy adult rabbits},
  author={Mohammad Kazem Koohi and M. Seyyed Hejazy and Farzad Asadi and Peyman Asadian},
  year={2011}
}
The purpose of this study is to evaluate the dermal toxicity (Irritation/Corrosion) of three sizes of nanosilver particles (10, 20 and 30 nm) during 3 min, 1 and 4 hours according to the OECD/OCDE guideline Histopathological effects in secondary organs from liver, kidney, heart, spleen and brain 14 day post dermal administration are also reported. 10 and 20 nm Ag nanoparticles treated group showed well defined dermal erythema and oedema. Histopathological findings of 10 and 20 nm (4 hours… CONTINUE READING

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