Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction.


BACKGROUND The precise mechanism of takotsubo-like left ventricular (LV) dysfunction remains unclear. METHODS AND RESULTS Eight consecutive patients with takotsubo-like LV dysfunction were studied. In the acute phase and 3 weeks later, the coronary flow velocity spectrum and coronary flow velocity reserve (CFVR) were recorded by Doppler guidewire. The deceleration time of diastolic velocity (DDT; ms) was measured from the peak diastolic velocity to the point where the extrapolated line intersected the baseline. In all cases, CFVR of the 3 coronary arteries increased during follow-up (1.7+/-0.5 to 2.4+/-0.5 for the left anterior descending artery (p < 0.05), 1.7+/-0.5 to 2.7+/-0.8 for the left circumflex artery (p < 0.05) and 1.7+/-0.3 to 2.5+/-0.4 for the right coronary artery (p < 0.05)). In addition, the DDT of all coronary arteries increased during follow-up. CONCLUSIONS Decreased CFVR and short DDT were demonstrated in patients with takotsubo-like transient LV dysfunction in the acute phase, and these findings improved 3 weeks later, which suggests that coronary microvascular dysfunction may be a causative mechanism.

4 Figures and Tables

Citations per Year

456 Citations

Semantic Scholar estimates that this publication has 456 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Kume2005AssessmentOC, title={Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction.}, author={Teruyoshi Kume and Takashi Akasaka and Takahiro Kawamoto and Hidetoshi Yoshitani and Nozomi Watanabe and Yoji Neishi and Nozomi Wada and Kiyoshi Yoshida}, journal={Circulation journal : official journal of the Japanese Circulation Society}, year={2005}, volume={69 8}, pages={934-9} }