Assessment of complement C4 gene copy number using the paralog ratio test.

Abstract

The complement C4 locus is in the class III region of the MHC, and exhibits copy number variation. Complement C4 null alleles have shown association with a number of diseases including systemic lupus erythematosus (SLE). However, most studies to date have used protein immunophenotyping and not direct interrogation of the genome to determine C4 null allele… (More)
DOI: 10.1002/humu.21259

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