Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum.

@article{Yamauchi2012AssessmentOC,
  title={Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum.},
  author={Mai Yamauchi and Teppei Morikawa and Aya Kuchiba and Y U Imamura and Zhi Rong Qian and Reiko Nishihara and Xiaoyun Liao and Levi Waldron and Yujin Hoshida and Curtis Huttenhower and Andrew T. Chan and Edward L. Giovannucci and Charles Fuchs and Shuji Ogino},
  journal={Gut},
  year={2012},
  volume={61 6},
  pages={847-54}
}
OBJECTIVE Colorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour location. Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that tumour molecular features might gradually change along bowel subsites, rather than change abruptly at splenic flexure. DESIGN Utilising 1443 colorectal cancers in two US nationwide prospective cohort studies… CONTINUE READING
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