Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum

@article{Yamauchi2012AssessmentOC,
  title={Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum},
  author={M. Yamauchi and T. Morikawa and A. Kuchiba and Y. Imamura and Z. Qian and R. Nishihara and X. Liao and Levi Waldron and Y. Hoshida and C. Huttenhower and A. Chan and E. Giovannucci and C. Fuchs and S. Ogino},
  journal={Gut},
  year={2012},
  volume={61},
  pages={847 - 854}
}
  • M. Yamauchi, T. Morikawa, +11 authors S. Ogino
  • Published 2012
  • Medicine
  • Gut
  • Objective Colorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour location. Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that tumour molecular features might gradually change along bowel subsites, rather than change abruptly at splenic flexure. Design Utilising 1443 colorectal cancers in two US nationwide prospective cohort studies… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 61 REFERENCES
    Are there two sides to colorectal cancer?
    • 628
    CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • 688
    • Open Access