Assessment of chromosomal aberrations, micronuclei and proliferation rate index in peripheral lymphocytes from Tunisian nurses handling cytotoxic drugs.

@article{Bouraoui2011AssessmentOC,
  title={Assessment of chromosomal aberrations, micronuclei and proliferation rate index in peripheral lymphocytes from Tunisian nurses handling cytotoxic drugs.},
  author={Sana Bouraoui and Aicha Brahem and Faten Debbabi Tabka and Najib Mrizek and Ali Kandil Saad and Hatem Elghezal},
  journal={Environmental toxicology and pharmacology},
  year={2011},
  volume={31 1},
  pages={
          250-7
        }
}
Anti-neoplastic agents are widely used in the treatment of cancer and some non-neoplastic diseases. These drugs have been proved to be mutagens, carcinogens and teratogens. To check the eventual effects of anti-cancer drugs on occupationally exposed Tunisian nurses, we used chromosomal aberration assay and micronucleus assay. Both parameters have been used to evaluate cellular DNA damage in the biological monitoring of occupationally exposed workers and each assay has its own aim .We used the… CONTINUE READING
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