Assessment of chemical skin-sensitizing potency by an in vitro assay based on human dendritic cells.

@article{Lambrechts2010AssessmentOC,
  title={Assessment of chemical skin-sensitizing potency by an in vitro assay based on human dendritic cells.},
  author={Nathalie Lambrechts and H Vanheel and Inge Nelissen and Hilda E. Witters and Rosette van den Heuvel and Viggo F. I. Van Tendeloo and Greet E R Schoeters and Jef J. D. Hooyberghs},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={116 1},
  pages={
          122-9
        }
}
The skin-sensitizing potential of chemicals is an important concern for public health and thus a significant end point in the hazard identification process. To determine skin-sensitizing capacity, large research efforts focus on the development of assays, which do not require animals. As such, an in vitro test has previously been developed based on the differential expression of CREM and CCR2 transcripts in CD34(+) progenitor-derived dendritic cells (CD34-DC), which allows to classify chemicals… CONTINUE READING

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