Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening.

@article{Radio2008AssessmentOC,
  title={Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening.},
  author={Nicholas M Radio and Joseph M Breier and Timothy J. Shafer and William R. Mundy},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={105 1},
  pages={106-18}
}
Identification of chemicals that pose a hazard to the developing nervous system is the first step in reducing human exposure and preventing health risks to infants and children. In response to the need for more efficient methods to identify potential developmental neurotoxicants, the present study evaluated the utility of an automated high content screening system to detect chemical effects on neurite outgrowth in Neuroscreen-1 cells (NS-1), a subclone of PC12 cells. Plating 2000 NS-1 cells per… CONTINUE READING

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