Assessment of changes in murine tumor oxygenation in response to nicotinamide using 19F NMR relaxometry of a perfluorocarbon emulsion.

Abstract

The oxygen dependencies of the 19F NMR spin-lattice relaxation rates (R1 = 1/T1) of a perfluorocarbon emulsion sequestered in a murine tumor model has been used to evaluate nicotinamide, a radiosensitizer believed to act through enhanced tissue oxygenation. Fluorine-19 NMR spectroscopic measurements from solid Radiation-Induced Fibrosarcoma (RIF-1) tumors… (More)

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