Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies.

@article{Adler2010AssessmentOC,
  title={Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies.},
  author={Melanie Adler and Dana Hoffmann and Heidrun Ellinger-Ziegelbauer and Philip R Hewitt and Katja A Matheis and Laoighse Mulrane and William M. Gallagher and John. J. Callanan and Laura Suter and Michael Fountoulakis and Wolfgang Dekant and Angela Mally},
  journal={Toxicology letters},
  year={2010},
  volume={196 1},
  pages={1-11}
}
This study was designed to assess the value of a set of potential markers for improved detection of liver injury in preclinical toxicity studies. Male Wistar rats were treated with drug candidates (BAY16, EMD335823, BI-3) that previously failed during development, in part due to hepatotoxicity, at two dose levels for 1, 3 and 14 days. Concentrations of… CONTINUE READING