Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma—a Nordic Lymphoma Group study

@article{Jerkeman2004AssessmentOB,
  title={Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma—a Nordic Lymphoma Group study},
  author={Mats Jerkeman and Harald Anderson and Michael Dictor and Stein Kval\oy and M. A. Akerman and Eva K Cavallin-St{\aa}hl},
  journal={Annals of Hematology},
  year={2004},
  volume={83},
  pages={414-419}
}
The purpose of this study was to investigate the prognostic effects of four biological markers, BCL2, TP53, Ki-67, and P-glycoprotein, and their possible clinical relevance in addition to the international prognostic index (IPI) in diffuse large B-cell lymphoma (DLBCL). A total of 405 patients with aggressive lymphoma, stage II-IV, between 18 and 67 years, were randomized in a trial comparing CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with MACOP-B (methotrexate… CONTINUE READING

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