Assessment of biocompatibility and initial evaluation of genipin cross-linked elastin-like polypeptides in the treatment of an osteochondral knee defect in rabbits.

@article{Hrabchak2010AssessmentOB,
  title={Assessment of biocompatibility and initial evaluation of genipin cross-linked elastin-like polypeptides in the treatment of an osteochondral knee defect in rabbits.},
  author={Christopher Hrabchak and Jessica Rouleau and Isaac L. Moss and Kimberly Woodhouse and Margarete K Akens and Catherine M Bellingham and Fred W. Keeley and Madison Dennis and Albert Y. Yee},
  journal={Acta biomaterialia},
  year={2010},
  volume={6 6},
  pages={2108-15}
}
Polypeptides based on the alternating hydrophobic and cross-linking domain structure of human elastin are capable of undergoing self-assembly to produce polymeric matrices with unique biological and mechanical properties. Here, we test the initial feasibility of using a genipin cross-linked elastin-based material as an acellular plug in the treatment of an osteochondral defect in the rabbit knee. Full-thickness defects in the weight-bearing surface of the medial femoral condyle in 18 New… CONTINUE READING