Assessment of axonal loss in Charcot-Marie-Tooth neuropathies.

  title={Assessment of axonal loss in Charcot-Marie-Tooth neuropathies.},
  author={Victoria H Lawson and A Gordon Smith and Mark B. Bromberg},
  journal={Experimental neurology},
  volume={184 2},
Sensory loss and weakness in Charcot-Marie-Tooth (CMT) neuropathy is due to axonal loss. However, the pattern and degree of axonal loss cannot be accurately determined from routine electrodiagnostic or strength testing due to collateral reinnervation. We sought to quantify axonal loss in two upper extremity muscles in CMT1A and CMT2 subjects using the… CONTINUE READING