Assessment of apixaban plasma levels by laboratory tests: suitability of three anti-Xa assays. A multicentre French GEHT study.

@article{GouinThibault2014AssessmentOA,
  title={Assessment of apixaban plasma levels by laboratory tests: suitability of three anti-Xa assays. A multicentre French GEHT study.},
  author={Isabelle Gouin-Thibault and Claire Flaujac and Xavier Delavenne and Sara Quenet and M H Horellou and Silvy Laporte and Virginie Siguret and Thomas Pierre Lecompte},
  journal={Thrombosis and haemostasis},
  year={2014},
  volume={111 2},
  pages={240-8}
}
While laboratory monitoring is not required in patients treated with apixaban, a direct factor-Xa inhibitor, assessment of its concentration is useful in some critical situations. However, few data are available on its effect on coagulation tests and on the suitability of anti-Xa assays for its quantification. It was the objective of this study to identify laboratory tests suitable for apixaban concentration assessment. Coagulation tests - PT and aPTT- and anti-Xa assays were performed in… CONTINUE READING

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