Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials.

@article{Charles2000AssessmentOA,
  title={Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials.},
  author={Peter J. Charles and R. J. T. Smeenk and Jos de Jong and Marc Feldmann and Ravinder N. Maini},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 11},
  pages={2383-90}
}
OBJECTIVE To compare the incidence of anti-double-stranded DNA (anti-dsDNA) antibodies in rheumatoid arthritis (RA) patients receiving either single or multiple doses of a chimeric anti-tumor necrosis factor alpha (anti-TNFalpha) antibody or placebo infusions, with or without methotrexate, in open-label, randomized, placebo-controlled trials. METHODS Multiple sera obtained from 156 patients before and after treatment with infliximab and from 37 patients treated with placebo infusions were… CONTINUE READING
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